1000 The impact of the skin microbiome in psoriasis capitis

Human skin is covered with billions of microbes and hosts a diverse community bacterial, fungal, archaeal, viral species. Psoriasis an immune mediated inflammatory disorder global prevalence 2-4%, whereas 75-90% the patients suffer from psoriasis capitis. An under-studied area scalp microbiome impact both fungal bacterial species have on conditions. Our overall objective to examine how changes in normal cutaneous contribute pathogenesis capitis find metagenomic biomarkers that explain differences between microbial communities. Within our study, 83 samples healthy participants, 68 lesional non-lesional untreated test subjects were collected. The analyzed shotgun metagenomics (12M reads) subset was also sent for amplicon sequencing (16S rRNA ITS region) map subjects. Shallow data revealed scalps merely bacteria, followed by fungi, protists species, dominated Cutibacterium, Staphylococcus Malassezia. most abundant Cutibacterium acnes Malassezia restricta. Inflamed psoriatic contained significantly less (α-diversity), different composition (β-diversity) comparison non-inflamed skin. Differential detected healthy, lesional, can be used as biomarkers. Scalp lesions more Corynebacterium otidis, ihumii, Acinetobacter junii, obtusa Pichia fermentans compared Overall, this study shows small but clear altered nonetheless not cause rather consequence inflamed